{"id":424,"date":"2020-02-16T11:25:43","date_gmt":"2020-02-16T05:55:43","guid":{"rendered":"https:\/\/medicineplexus.com\/?p=424"},"modified":"2020-02-16T11:25:43","modified_gmt":"2020-02-16T05:55:43","slug":"evaluation-of-antidepressant-drugs","status":"publish","type":"post","link":"https:\/\/medicineplexus.com\/evaluation-of-antidepressant-drugs\/","title":{"rendered":"Evaluation of antidepressant drugs"},"content":{"rendered":"\n
Evaluation of antidepressant drugs<\/u><\/em><\/strong><\/p>\n\n\n\n Need for new drugs:<\/strong><\/p>\n\n\n\n In-vitro assay.<\/strong><\/p>\n\n\n\n Receptor binding assay<\/strong>:<\/p>\n\n\n\n Measurement of beta-adrenoceptor stimulated adenylate cyclase<\/strong>:<\/p>\n\n\n\n Assays for determining decreased uptake of the amines<\/strong>: (Norepinephrine\/Dopamine\/Serotonin)<\/strong><\/p>\n\n\n\n In Vivo<\/strong><\/p>\n\n\n\n 1. Gross behavior test.<\/p>\n\n\n\n 2. Test based on inhibition of amine uptake.<\/p>\n\n\n\n 3. Test Based on anticholinergic activity.<\/p>\n\n\n\n 4. Test based on depletion of biogenic amine.<\/p>\n\n\n\n 5. Hypermotility in olfactory-bulbectomized rats<\/p>\n\n\n\n Forced swimming test.<\/strong><\/p>\n\n\n\n Final Observation <\/em><\/strong>\u00e0 Immobility time during 6 mins (360 seconds)<\/em><\/strong><\/p>\n\n\n\n Adv<\/strong>: Relative simplicity<\/p>\n\n\n\n Limitation<\/strong><\/p>\n\n\n\n Tail suspension test in mice<\/strong><\/p>\n\n\n\n Disadv: Several mouse strains are inherently resistant to TST.<\/p>\n\n\n\n Learned helplessness model.<\/strong><\/p>\n\n\n\n Muricide behavior in rats<\/strong><\/p>\n\n\n\n Tests based on inhibition of amine reuptake<\/strong><\/p>\n\n\n\n Potentiation of NE toxicity in mice:<\/strong><\/p>\n\n\n\n Potentiation of 5HTP (5 hydroxy tryptophan) in mice:<\/strong><\/p>\n\n\n\n Potentiation of 5HTP (5 hydroxy tryptophan) in rats.<\/strong><\/p>\n\n\n\n Compulsive gnawing in mice<\/strong>.<\/p>\n\n\n\n Tests based on depletion of monoamines<\/strong><\/p>\n\n\n\n Other models<\/p>\n\n\n\n <\/p>\n","protected":false},"excerpt":{"rendered":" Evaluation of antidepressant drugs Need for new drugs: High suicide rates in severe depression even if pharmacotherapy is available. 1\/3rd patients are resistant. Some patients show low compliance. All presently available class of drugs are a\/w numerous s\/e. In-vitro assay. Receptor binding assay: Isolate the appropriate cells with receptors of interest. Add radioactive ligand in[…]\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/posts\/424"}],"collection":[{"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/comments?post=424"}],"version-history":[{"count":0,"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/posts\/424\/revisions"}],"wp:attachment":[{"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/media?parent=424"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/categories?post=424"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/tags?post=424"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}