{"id":597,"date":"2020-02-17T20:25:58","date_gmt":"2020-02-17T14:55:58","guid":{"rendered":"https:\/\/medicineplexus.com\/?p=597"},"modified":"2020-02-17T20:25:58","modified_gmt":"2020-02-17T14:55:58","slug":"insulin-analogues","status":"publish","type":"post","link":"https:\/\/medicineplexus.com\/insulin-analogues\/","title":{"rendered":"Insulin Analogues"},"content":{"rendered":"\n
Insulin Analogues<\/strong><\/p>\n\n\n\n Molecules produced by genetic engineering wherein the amino acid sequence in human insulin is changed to alter its pharmacokinetics.<\/p>\n\n\n\n However, they bind to insulin receptors in the same way as human insulin and produce similar effects<\/p>\n\n\n\n Also termed as Designer Insulins<\/strong>, Insulin receptor ligands, Democratic insulins<\/p>\n\n\n\n Novel short or long acting insulin analogues also called \u2018designer insulin\u2019.<\/strong><\/p>\n\n\n\n Actions<\/strong><\/p>\n\n\n\n 1. It decreases blood glucose by<\/p>\n\n\n\n \u2022 Stimulating the entry of glucose in muscle and fat<\/strong> (by increasing the synthesis of GLUT 4).<\/p>\n\n\n\n \u2022 Inhibiting glycogenolysis<\/strong> (by inhibiting phosphorylase) and gluconeogenesis<\/strong> (by inhibiting phosphoenol pyruvate carboxykinase). These processes are inhibited at lower concentration of insulin.<\/p>\n\n\n\n \u2022 Increasing glycolysis<\/strong> (by stimulation of glucokinase) and glycogenesis (by stimulating glycogen synthase). These require more concentration of insulin.<\/p>\n\n\n\n 2. It inhibits lipolysis<\/strong> and thus favors triglyceride deposition.<\/strong><\/p>\n\n\n\n 3. It increases the synthesis and inhibits the breakdown of proteins.<\/strong><\/p>\n\n\n\n