{"id":691,"date":"2020-02-17T20:48:54","date_gmt":"2020-02-17T15:18:54","guid":{"rendered":"https:\/\/medicineplexus.com\/?p=691"},"modified":"2020-02-17T20:48:54","modified_gmt":"2020-02-17T15:18:54","slug":"pharmacotherapy-of-obesity","status":"publish","type":"post","link":"https:\/\/medicineplexus.com\/pharmacotherapy-of-obesity\/","title":{"rendered":"Pharmacotherapy of Obesity"},"content":{"rendered":"\n
Pharmacotherapy of Obesity<\/strong><\/strong><\/p>\n\n\n\n Introduction<\/strong><\/strong><\/p>\n\n\n\n Multifactorial disorder<\/p>\n\n\n\n \u2022 Leptin is synthesized and secreted primarily from adipocytes and acts centrally in the hypothalamus by binding to the leptin receptor. Circulating levels of leptin are highly correlated with the level of body fat.<\/p>\n\n\n\n \u2022 Insulin and glucocorticoids can stimulate production of leptin by adipocytes. Low plasma concentrations of leptin and insulin, e.g. during fasting and weight loss, increase food intake and decrease energy expenditure by stimulating neuropeptide Y (NPY) synthesis, and perhaps by inhibiting sympathetic activity and other catabolic pathways.<\/p>\n\n\n\n \u2022 High leptin and insulin concentrations, e.g. during feeding and weight gain, decrease food intake and increase energy expenditure through release of melanocortin and corticotropin-releasing hormone (CRH).<\/p>\n\n\n\n \u2022 Stimulation of the leptin receptor can lead to changes in the expression of a variety of neuropeptides.<\/p>\n\n\n\n \u2022 Neuropeptides that are involved in energy homeostasis can be orexigenic (appetite stimulating) and anorectic<\/p>\n\n\n\n