{"id":695,"date":"2020-02-17T20:52:41","date_gmt":"2020-02-17T15:22:41","guid":{"rendered":"https:\/\/medicineplexus.com\/?p=695"},"modified":"2020-02-17T20:52:41","modified_gmt":"2020-02-17T15:22:41","slug":"acute-paracetamol-poisoning","status":"publish","type":"post","link":"https:\/\/medicineplexus.com\/acute-paracetamol-poisoning\/","title":{"rendered":"Acute paracetamol poisoning"},"content":{"rendered":"\n
Acute paracetamol poisoning<\/strong><\/p>\n\n\n\n Clinical factors that can predispose patients to injury from acetaminophen ingestion include<\/p>\n\n\n\n Chronic acetaminophen poisoning in the alcohol user is also characterized by markedly elevated aminotransferases (>3000 IU\/L), combined with hypovolemia, jaundice, coagulopathy, hypoglycemia, and acute renal failure in greater than 50 percent of these patients.<\/p>\n\n\n\n Mechanism of toxicity<\/strong><\/p>\n\n\n\n The Drugs Controller General of India (DCGI) \u00e0 (2011) issued guidelines to limit the amount of paracetamol per dosage form (single tab.\/cap.) to 325 mg.<\/p>\n\n\n\n Treatment<\/strong><\/p>\n\n\n\n Specific: N-acetylcysteine<\/strong> 150 mg\/kg should be infused i.v. over 15 min, followed by the same dose i.v. over the next 20 hours.<\/p>\n\n\n\n Alternatively, 75 mg\/kg may be given orally every 4\u20136 hours for 2\u20133 days.<\/p>\n\n\n\n