{"id":834,"date":"2020-02-17T22:12:11","date_gmt":"2020-02-17T16:42:11","guid":{"rendered":"https:\/\/medicineplexus.com\/?p=834"},"modified":"2020-02-17T22:12:11","modified_gmt":"2020-02-17T16:42:11","slug":"selective-estrogen-receptor-modulators-serm","status":"publish","type":"post","link":"https:\/\/medicineplexus.com\/selective-estrogen-receptor-modulators-serm\/","title":{"rendered":"Selective Estrogen Receptor Modulators (SERM)"},"content":{"rendered":"\n
SERM<\/strong><\/p>\n\n\n\n Selective Estrogen Receptor Modulators (SERM)<\/strong><\/p>\n\n\n\n Three agents are available that act as SERMs:\u00a0tamoxifen,\u00a0raloxifene, and\u00a0toremifene\u00a0<\/p>\n\n\n\n The mixed antagonist\/agonist effect of SERMs on ERs can be illustrated by their physiological effects in postmenopausal women:<\/strong><\/p>\n\n\n\n SERMs \u00e0<\/p>\n\n\n\n In early cases tamoxifen is given as postmastectomy adjuvant therapy, while in advanced cases, it is a constituent of palliative treatment.<\/strong><\/p>\n\n\n\n INTERACTIONS OF SERDS AND SERMS WITH THE ER<\/strong><\/p>\n\n\n\n Tamoxifen<\/strong>\u00a0\u2014\u00a0<\/p>\n\n\n\n