{"id":978,"date":"2020-02-18T11:22:48","date_gmt":"2020-02-18T05:52:48","guid":{"rendered":"https:\/\/medicineplexus.com\/?p=978"},"modified":"2020-02-18T11:22:48","modified_gmt":"2020-02-18T05:52:48","slug":"reverse-pharmacology","status":"publish","type":"post","link":"https:\/\/medicineplexus.com\/reverse-pharmacology\/","title":{"rendered":"Reverse Pharmacology"},"content":{"rendered":"\n
Reverse Pharmacology<\/u><\/strong><\/p>\n\n\n\n Reverse Pharmacology (RP) is a science of integrating documented experiential hits, into leads by transdisciplinary exploratory studies and further developing into drug candidates by experimental research.<\/strong><\/p>\n\n\n\n In this approach, the candidate travels a reverse path from \u2018clinics to laboratory\u2019<\/strong> rather than classical \u2018laboratory to clinics’.<\/strong><\/p>\n\n\n\n History of Reverse Pharmacology in India<\/strong><\/p>\n\n\n\n Sir Ram Nath Chopra<\/strong> was a pioneer in the field of experimental pharmacology of indigenous drugs of India. Along with Gananath Sen<\/strong> he laid the foundation of RP of medicinal plants<\/strong> by pursuing clinically documented effects of Ayurvedic drugs.<\/p>\n\n\n\n Sen and Kartik Bose in 1931 demonstrated the antihypertensive and tranquilizing effect of Rawolfia serpentina.<\/em><\/strong><\/p>\n\n\n\n Scope of Reverse Pharmacology<\/strong><\/p>\n\n\n\n Salient features of reverse pharmacology<\/u><\/strong>:<\/p>\n\n\n\n The path of classical and reverse pharmacology approach<\/u><\/strong>:<\/p>\n\n\n\n Research and development path for natural products<\/u><\/strong>:<\/p>\n\n\n\n The different paths of development of botanical medications are:<\/p>\n\n\n\n The drawbacks of these botanical medications are<\/u><\/strong>:<\/strong><\/p>\n\n\n\n Reverse pharmacology provides an open \u2013 ended approach, to guide us from the traditional wisdom of Ayurveda to the current state-of-art developments in biology. It offers a major paradigm shift in drug discovery. Instead of serendipitous findings pursued randomly, an organized path from clinical observations and successes is established.<\/p>\n\n\n\n R & D path for natural products<\/u><\/strong>:<\/p>\n\n\n\n Reverse Pharmacology and Ayurveda<\/u><\/strong>:<\/p>\n\n\n\n Ayurvedic knowledge and experiential database can provide new functional leads to reduce time, money and toxicity – the three main hurdles in the drug development.<\/p>\n\n\n\n Basic principle of Ayurveda is based on personalized approach can be used for creating personalized, customized or designer medicines. Therefore, science of Ayurveda has the potential to revolutionize modern medicine and drug discovery processes.<\/p>\n\n\n\n A golden triangle consisting of Ayurveda, modern medicine and science will converge to form a real discovery engine that can result in newer, safer, cheaper and effective therapies.<\/p>\n\n\n\n The salient features of drug discovery by reverse pharmacology through Ayurveda are<\/u><\/strong>:<\/p>\n\n\n\n The approach has attracted considerable attention, nationally and internationally: Central Scientific Instrumental Research (CSIR)<\/strong> and Indian Council of Medical Research (ICMR)<\/strong> have done clinical trials with natural products.<\/strong> Moreover, Central Council for Research in Ayurveda and Siddha (CCRAS) <\/strong>has recently adopted the golden triangle approach for some new indications of old drugs, as well as for Ayurveda.<\/p>\n\n\n\n A New Millennium for Technological Leadership Initiative (NMITLI) has resulted in hits, leads and effective formulations for diabetes, arthritis and hepatitis with novel mechanism of action and intellectual property as shown in the following table.<\/p>\n\n\n\n Phases of reverse pharmacology<\/strong>:<\/p>\n\n\n\n RP can be perceived to comprise of three phases or domains.<\/p>\n\n\n\n The progress of RP in India has led to the following leads from Ayurvedic medicinal plants:<\/p>\n\n\n\n Thus, the Reverse pharmacology as an organized trans-discipline would fill up the gaps between the serendipity and research creativity.<\/p>\n","protected":false},"excerpt":{"rendered":" Reverse Pharmacology Reverse Pharmacology (RP) is a science of integrating documented experiential hits, into leads by transdisciplinary exploratory studies and further developing into drug candidates by experimental research. In this approach, the candidate travels a reverse path from \u2018clinics to laboratory\u2019 rather than classical \u2018laboratory to clinics’. RP enhances the connection, communication and collaboration between[…]\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/posts\/978"}],"collection":[{"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/comments?post=978"}],"version-history":[{"count":0,"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/posts\/978\/revisions"}],"wp:attachment":[{"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/media?parent=978"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/categories?post=978"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicineplexus.com\/wp-json\/wp\/v2\/tags?post=978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Disease<\/strong><\/td> Plants<\/strong><\/td> Ayurvedic forms<\/strong><\/td> Phytoactives<\/strong><\/td><\/tr> Diabetes mellitus<\/td> P. emblica<\/em> E. littorale<\/em><\/td> Fruits-Chyavanprash Entire plant ghana<\/td> Gallic acid Swertiamarin<\/td><\/tr> Arthritis<\/td> T. cordifolia<\/em> S. anacardum<\/em><\/td> Amrita bhallatak Avaleha<\/td> Polysaccharide Bhilawanol<\/td><\/tr> hepatitis<\/td> Multi-ingredients<\/em><\/td> Phalaghrita<\/td> Multiple<\/td><\/tr> Psoriasis<\/td> A. mexicana<\/em><\/td> Latex ghana<\/td> Berberine<\/td><\/tr> NASH<\/td> P. karroa<\/em><\/td> Powder<\/td> Picroside 2<\/td><\/tr> Malaria<\/td> N. arbor-tristis<\/em><\/td> Leaves-paste<\/td> unknown<\/td><\/tr> Pre-cancer Lesions<\/td> C. longa<\/em><\/td> Powder<\/td> Curcumin<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n