{"id":981,"date":"2020-02-18T11:27:26","date_gmt":"2020-02-18T05:57:26","guid":{"rendered":"https:\/\/medicineplexus.com\/?p=981"},"modified":"2020-02-18T11:27:26","modified_gmt":"2020-02-18T05:57:26","slug":"translational-pharmacology","status":"publish","type":"post","link":"https:\/\/medicineplexus.com\/translational-pharmacology\/","title":{"rendered":"Translational Pharmacology"},"content":{"rendered":"\n
Translational Pharmacology<\/strong><\/p>\n\n\n\n Branch of pharmacology that tries to bridge the gap between the basic molecular research studies to the clinical trials.<\/strong><\/p>\n\n\n\n Translational Pharmacology, translational research and translational medicine are the interchangeable terminologies where<\/p>\n\n\n\n translational research is an inter-disciplinary branch of a biomedical field that are greatly supported by three main pillars<\/strong><\/p>\n\n\n\n Translational pharmacology includes:<\/p>\n\n\n\n There exists a gap between the need, development and the availability of the medicines<\/strong>.<\/p>\n\n\n\n specific systematic attempts reproduce preclinical findings, with very low success rates \u00e0 failures are attributed to a variety of factors, including<\/p>\n\n\n\n several systematic analyses of the causes of major pharma pipeline attrition up to phase 2 of development.<\/p>\n\n\n\n Translational pharmacology helps to bridge this gap.<\/p>\n\n\n\n For academia, translational pharmacology encourages the individuals in the field of research, to test their novel ideas, that are generated from basic investigation hoping for their clinical applications.<\/p>\n\n\n\n While for physicians or the clinical practitioners it facilitates to capture the research benefits and to understand what is known and what is practiced.<\/p>\n\n\n\n While, as for the commercial pharmaceutical industry it measures assessment of the new entities at earlier phases, to identify the problems early, so as to solve them at an early stage to reduce the cost of product development.<\/p>\n\n\n\n The bench to bedside concept <\/strong><\/strong><\/p>\n\n\n\n Proper design, execution and reporting of animal model results help to make preclinical data more reproducible and translatable to the clinic. Hence, critical evaluation of the face and predictive validity<\/strong> of these models is important. Reversely, clinical bedside findings that were not predicted by animal testing should be back translated and used to refine the animal models<\/strong>.<\/p>\n\n\n\n Objectives<\/strong><\/sup><\/strong><\/p>\n\n\n\n Translational Medicine department has three guiding principles:<\/p>\n\n\n\n (1) pick the right targets,<\/p>\n\n\n\n (2) develop the right biomarkers to measure target modulation, and<\/p>\n\n\n\n (3) test therapeutic hypotheses as safely, quickly and efficiently as possible.<\/p>\n\n\n\n Phases of translational research<\/strong><\/sup><\/strong><\/p>\n\n\n\n Valley of death<\/strong><\/p>\n\n\n\n Translating the knowledge from biomedical science into clinical applications that help patients has been compared to crossing a valley of death because of the many issues that separate the bench from the bedside and threaten to stall progress<\/p>\n\n\n\n